New formulations from Acacia nilotica L and Glycyrrhiza glabra L. for oral ulcer remedy

This study addresses the innovation of a stable new pharmaceutical formulation comprising natural botanical extracts of Acacia nilotica L. and Glycyrrhiza glabra L., which are therapeutically effective in the treatment of oral ulcer and possess high patient acceptability. The pastes are prepared, characterized, and subjected to physical and chemical stability studies and then evaluated for therapeutic efficacy regarding ulcer size. The novel adhesive paste is prepared and when applied to the oral mucosa, it remains on it for a considerable period of time. The stability tests of all the samples in the analysis showed satisfactory physical and chemical stability evaluated by the Normal Stability Test. The muco adhesive paste incorporating the active; A. nilotica L, when applied to oral ulcer, could promote the healing process, leading to a decrease in diameter of the inflammatory halo of the ulcer. However, the effect of liquorice extract on recurrent aphthous ulceration [RAU] was found even better than that of acacia extract. A combination of the two plants presented a synergism of both, leading to better healing with favorable reduction of the diameter of inflammatory halo of the ulcer together with a prolonged action. Therapeutically, effective and stable oral pastes are dispensed with cost-effective benefits

Phytochemical study and evaluation of the anti-inflammatory activity of some medicinal plants growing in Egypt

The anti-inflammatory activity of different extracts of five plants abundantly growing in Egypt, namely Ipomoea palmate Forsk. [Convolvulaceae], Alstonia scholaris R.Br. [Apocynaceae], Salix subserrata Willd., Salix tetrasperma Roxb, and Populus nigra Linn. [Salicaceae] has been studied. Phytochemical study on selected bioactive extracts was carried out as well as their possible mechanism of action. The results revealed a significant anti-inflammatory activity of the extracts under investigation to different degrees. A chromatographic study of the bioactive lipoidal extracts of A. scholaris and I. palmate was carried out and the results revealed the presence of unsaturated fatty acids [linoleic and linoleic]. Beta-sitosterol and campesterol were present in A. scholaris and I. palmate, respectively. Chromatographic and spectral investigation of the flavonoids in the bioactive aqueous extract of I. palmate revealed the presence of luteolin, quercetin 7-glycosie and apigenin. The anti-inflammatory activity may be due to the presence of these phytochemical constituents

Phytochemical and biological studies of some polysaccharides isolated from aloe, tamarindus, opuntia and citrus

The aim of this study is the phytochemical and biological evaluation of polysaccharides isolated from some medicinal plants belonging to the Genera Aloe, Tamarindus, Opuntia and Citrus. Antihyperglycemic, anti-inflammatory, immunomodulatory and antioxidant of the polysaccharides were studied. Extraction, isolation and identification of the biologically active constituents have been carried out aiming at discovery of new active constituents from botanical origin which can be utilized in drug industry. The Polysaccharides from the plants under investigation were isolated using cold and hot extraction methods then hydrolysed, the polysaccharide hydrolysates were identified by Paper and HPLC chromatographic techniques. The isolated polysaccharides were tested for their anti-inflammatory, antioxidant, hypoglycemic and immunomodulating activities. The optimum parameters for the extraction of polysaccharides isolated from the seeds of Tamarindus indica Linn. Family Leguminosae were examined by using three factor statistical techniques. Maximum yield of polysaccharides were obtained from Tamarindus indica Linn, seeds [21%], which was increased by varying temperature and time [55%]. The results of the biological activities revealed significant antihyperglycemic, immunomodulating, anti-inflammatory and antioxidant activities with variable degrees. Chromatographic investigation of the polysaccharide hydrolysates revealed the presence of hexoses, pentoses and uronic acids with qualitative and quantitative variations in the chemical composition. Tamarindus indica Linn, seeds had the highest yield of polysaccharide and the highest significant biological activities